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Vienna animal hospital3/24/2023 At the same time, the patterns of the muscle fibers are modified and, hence, the physiological properties of the autonomously reinnervated muscles are changed," explains first author Vlad Tereshenko, outlining the key findings from the study.įollowing injuries or certain diseases, nerves can temporarily or permanently lose their ability to provide motor control to muscles. As we have seen in our experiments, the parasympathetic nerve fibers form new functional neuromuscular synapses to do this. "Until now, we were unaware that the autonomic nervous system can control muscle motor function with nerve impulses. Using novel, complex techniques, they were able to establish that the autonomic nervous system takes over the function of the injured nerve, as it were. In some cases, the scientists observed spontaneous recovery of muscle function days or weeks after the nerve lesion. After a nerve has been injured or severed, it is no longer able to control the motor function of the facial muscles, resulting in facial paralysis in the animal model. The research team led by Vlad Tereshenko and Oskar Aszmann from the Clinical Laboratory for Bionic Limb Reconstruction at MedUni Vienna's Department of Plastic, Reconstructive and Aesthetic Surgery discovered this facet of the interaction between nerves and muscles-which was previously unknown to science-in the course of its preclinical research on facial nerves and muscles. Their findings may form the basis for improving and developing interventions to treat nerve lesions. The fact that this part of the nervous system also has the ability to spontaneously restore muscle function following a nerve injury was discovered by a research group at MedUni Vienna's Department of Plastic, Reconstructive and Aesthetic Surgery as part of their study recently published in the Journal of Neuroscience.
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